| Type | 4-door, 5-passenger full-size sedan |
| Layout | Front engine/rear-wheel drive/AWD |
| Engine | 3.5-litre V6, DOHC, 24 valves, with mild |
| hybrid system (S400) | |
| 4.6-litre V8, DOHC, 32 valves (S450) | |
| 5.5-litre V8, DOHC, 32 valves (S550) | |
| 5.5-litre V12, SOHC, 36 valves, | |
| twin-turbo (S600) | |
| 5.5-litre V8, DOHC, 32 valves, | |
| twin-turbo (S63 AMG) | |
| 6.0-litre V12, SOHC, 36 valves, | |
| twin-turbo (S65 AMG) | |
| Horsepower | 295 @ 6000 rpm (w/hybrid assist) |
| 335 @ 6000 rpm (S450) | |
| 382 @ 6000 rpm (S550) | |
| 510 @ 5000 rpm (S600) | |
| 536 @ 5500 rpm (S63 AMG) | |
| 603 @ 4800 rpm (S65 AMG) | |
| Torque (lb-ft) | 284 @ 2400 rpm (w/hybrid assist) |
| 339 @ 2700 rpm (S450) | |
| 391 @ 2800 rpm (S550) | |
| 612 @ 1800 rpm (S600) | |
| 590 @ 2000 rpm (S63 AMG) | |
| 738 @ 2000 rpm (S65 AMG) | |
| Transmission | 7-speed automatic (S400 Hybrid) |
| 7-speed automatic (S450) | |
| 7-speed automatic (S550) | |
| 5-speed automatic (S600) | |
| 7-speed automatic (S63 AMG) | |
| 5-speed automatic (S65 AMG) | |
| Tires S400, S450 | P255/45R18 all-season |
| Tires S550 | P255/40R19 performance |
| Tires S600 | P255/40R19 performance (front) |
| P275/40R19 performance (rear) | |
| Tires S63, S65 | P255/35R20 performance (front) |
| P275/35R20 performance (rear) | |
| Curb weight S400 Hybrid | 2050 kg (4519 lbs) |
| Curb weight S450, S550 | 2095 kg (4618 lbs) |
| Curb weight S600 | 2250 kg (4960 lbs) |
| Curb weight S63 | 2170 kg (4784 lbs) |
| Curb weight S65 | 2300 kg (5070 lbs) |
| Wheelbase | 3165 mm (124.6 in) |
| Wheelbase S450 | 3035 mm (119.4 in) |
| Length | 5206 mm (204.9 in) |
| Length S450 | 5079 mm (199.9 in) |
| Width S400 | 2120 mm (83.4in)(w/mirrors) |
| Width S450 | 2115 mm (83.2(w/mirrors) |
| Width S550, S600 | 2120 mm (83.4(w/mirrors) |
| Width S63, S65 | 2113 mm (83.1(w/mirrors) |
| Height | 473 mm (57.9 in) |
| Cargo capacity | 560 litres (19.7 cu.ft.) |
| Fuel consumption S400 | City: 11.0 L/100 km (26 mpg Imp) |
| Hwy: 7.7 L/100 km (37 mpg Imp) | |
| Fuel consumption S450 | City: 14.2 L/100 km (20 mpg Imp) |
| Hwy: 9.0 L/100 km (31 mpg Imp) | |
| Fuel consumption S550 | City: 14.9 L/100 km (19 mpg Imp) |
| Hwy: 9.3 L/100 km (30 mpg Imp) | |
| Fuel consumption S600 | City: 18.9 L/100 km (15 mpg Imp) |
| Hwy: 11.5 L/100 km (25 mpg Imp) | |
| Fuel consumption S63 | City: TBA |
| Hwy: TBA | |
| Fuel consumption S65 | City: 19.4 L/100 km (15 mpg Imp) |
| Hwy: 12.0 L/100 km (24 mpg Imp) | |
| Fuel type | Premium |
| Warranty | 4 yrs/80,000 km |
| Powertrain warranty | 4 yrs/80,000 km |
| Curtain airbags | Standard |
| Anti-lock brakes | Standard |
| Traction control | Standard |
| Stability control | Standard |
| Assembly location | Sindelfingen, Germany |

